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Molecular order imaging applications

Imaging lipid order in living tissues:

When associated to polarization-resolved measurement schemes, Lightcore Technologies DC-CRS microscope provides label-free chemical bond orientation in complex system such as mouse myelin sheath.

Molecular order imaging in lipids with DC-CRS
DC-CRS microscope resolved in polarization reveals the orientation of C-H bonds in mouse Myelin sheath. Field of view 150 µm x 150 µm.

Related publications:

  • P. Gasecka, A. Jaouen, F.-Z. Bioud, H. B. de Aguiar, J. Duboisset, P. Ferrand, H. Rigneault, N. K. Balla, F. Debarbieux, and S. Brasselet, "Lipid Order Degradation in Autoimmune Demyelination Probed by Polarized Coherent Raman Microscopy," Biophysical Journal 113, 1520-1530 (2017). doi.org/10.1016/j.bpj.2017.07.033
  • C. Cleff, A. Gasecka, P. Ferrand, H. Rigneault, S. Brasselet, and J. Duboisset, "Direct imaging of molecular symmetry by coherent anti-stokes Raman scattering," Nat Commun 7, 11562 (2016). doi.org/10.1038/ncomms11562