Chemical imaging / Pharmaceutical sciences applications

Mapping drug distribution in pharmaceutical products:

You are a chemical scientist and you want to image in a label-free manner chemical compounds in complex formulation or pharmaceutical tablets. Lightcore Technologies DC-CRS microscope provides a versatile and tunable platform to image chemical compounds through their vibrational signatures [500cm-1, 4000cm-1].

Chemical imaging of a tablet
DC-CRS microscope: Image of pharmaceutical tablet containing three excipients (PEG, Manitol, Starch) and two polymorph active molecules (A-F1 and A-F2).

Related publications:

  • B. Sarri, R. Canonge, X. Audier, V. Lavastre, G. Pénarier, J. Alie, and H. Rigneault, "Discriminating polymorph distributions in pharmaceutical tablets using stimulated Raman scattering microscopy," Journal of Raman Spectroscopy 50, 1896-1904 (2019). doi.org/10.1002/jrs.5743